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Previous Projects

Earlier Research Projects and Clinical Trials

  1. Response of docetaxel (taxotere) in metastatic CA breast.
  2. Study of the response of docetaxel (taxotere) in non small cell lung cancer stage III-B and stage IV as per TNM classification.
  3. Phase 2 study of gemcitabine plus cistplatin in chemotherapy naive- unresectable gall bladder cancer (code no. B-9E IN 0095).
  4. Pilot study - metastatic CA lung; role of texotere in metastatic CA lung; role of texotere in metastatic CA breast.
  5. Role of brachytherapy in brain cancer. 5 patients accrued presented at various forms.
  6. Multi-centric phase II study of gemictabine, paclitaxel and cisplatin in chemotherapy naïve advance ovarian cancer.
  7. Expression of P53 and NFKB tumour markers in head and neck cancers in collaboration with JNU, Delhi. This is the first time where NFKB marker is being studied along with P53 in head and neck cancers. Case accrual is complete and results are awaited.
  8. Concomitant administration of paclitaxel and radiotherapy in head and neck cancer, 20 patients accrued - ongoing.
  9. Gene therapy trial in lung cancer comparing conventional chemotherapy and gene therapy.
  10. Role of high resolution ultrasonography in staging of clinically node negative head & neck cancer.
  11. Prophylactic use of amifostine to prevent concomitant chemotherapy, radiotherapy induced mucositis and xerostomia in head and neck cancer.
  12. Pain scores post operatively after giving NSAID + Opiods + Homeopathy pre-operatively and post-operatively and accessing results.
  13. An open label single arm, multicentric study to assess the efficacy of oral factive (semi floxacin) for the empirical treatment in patients with respiratory tract infection.

Research Projects in Hand (2003 - 2004)

  1. Concomitant ternozolamide and radiotherapy in Glioblastoma Multiforme (GBM).
  2. Concomitant administration of paclitaxel and radiotherapy in head and neck cancer.
  3. Gene therapy trial in lung cancer comparing conventional chemotherapy and & gene therapy.
  4. Role of high reduction ultrasonography in staging of clinically node negative head & neck cancer.
  5. Testing of microsatellite instability on chromosome 17 in breast cancer.
  6. Phase-III study on CA breast (multi-center global trial) randomized trial comparing cyclophosphamide followed by docetaxel and herceptin (AC - TH) and with docetxal carboplatin and herceptin.

Research Projects in Hand (2004 - 2005)

  1. Analysis of genetic polymorpheris of P73 and P53 and the risk of cancers in Indian patients.
  2. Molecular analysis of FHIT gene and P16 and their association with HPV in Indian head and neck carcinoma patients.
  3. Nosocomial infection in OT multicentric trial.
  4. Pain scores post operatively after giving NSAID + Opiods + Homeopathy pre operatively and post operatively and accessing results.
  5. An open label single arm, multicentric study to assess the efficacy of oral factive (semi floxacin) for the empirical treatment in patients with respiratory tract infection.
  6. Cytological grading of CA breast on FNAC and its correlation with histological grading.
  7. Molecular markers in CA breast in collaboration with JNU.

Research Projects in Hand (2005 - 2006)

  1. Analysis of genetic polymorpheris of P73 and P53 and the risk of cancers in Indian patients.
  2. Molecular Analysis of FHIT gene and P16 and their association with HPV in Indian head and neck carcinoma patients.
  3. Nosocomial infection in OT multicentric trial.
  4. Pain scores post operatively after giving NSAID + Opiods + Homeopathy pre operatively and post operatively and accessing results.
  5. Prophylactic use of amifostine to prevent concomitant chemotherapy, radiotherapy induced mucositis and xerostomia in head and neck cancer.
  6. An open label single arm, multicentric study to assess the efficacy of oral factive (semi floxacin) for the empirical treatment in patients with respiratory tract infection.
  7. Cytological grading of CA breast on FNAC and its correlation with histological grading.
  8. Molecular markers in CA breast in collaboration with JNU.
  9. Evaluation of the efficacy and to leuability of capecitabire as a radiioensitizer in treatment of head and neck cancers.
  10. Prospective study of radical radiotherapy with concurrent weekly parlitanel in advanced insectable squamous cell CA of head and neck cancers.

Research Projects in Hand (2006 - 2007)

  1. Efficacy and safety of XMO1 compared to placebo in patients with solid tumours or non myeloid haematological tumours receiving non-platinum chemotherapy (XMO1-22) - A multinational, multi-center, randomized, placebo-controlled double blind parallel group phase- III study.
  2. Leuprolide acette depot injection in the treatment of advanced prostate cancer (Phase IV).
  3. Post marketing surveillance study of Gn PH against leuprogen leuprolide acetate depot injection 3.75 mg in the treatment of advanced prostate cancer (Phase IV study).
  4. The Patch Study - A randomized active control double blind, double dummy parallel group multinational study to assess the efficacy, tolerability and safety of Granisetron Transdermal Delivery System (GTDS) in Chemotherapy-induced Nausea and Vomiting (CINU) associated with the administration of moderately of highly emetogeine multi day chemotherapy.
  5. Molecular study of candidate genes on chromosome 16 sporadic breast cancers.
  6. Study of P53 mutations identification of hyploid sub and type of P53 in sporadic breast cancers.
  7. Analysis of genetic polymorpheris of P73 and P53 and the risk of cancers in Indian patients.
  8. Molecular analysis of FHIT gene and P16 and their association with HPV in Indian head and neck carcinoma patients.
  9. Airway assessment and management in head and neck cancers patients.
  10. Optimizing cancer radiotherapy with 2 DG dose escalation studies in patients with GBM
  11. Evaluation of efficacy and tolerability of capecitabine as a radiosensitizer in squramous cell carcinoma of head and neck.
  12. Evaluation of 2 DG as a radiomodifier in treatment of glioblastoma multiforme.
  13. Role of Intensity modulated radiation in head and neck cancers - Dharamshila's experience.
  14. Correlation of HER2 / (Cerb B2) grading on IHC with results of FISH on 2+ positive cases of infiltrating carcinoma.
  15. Cytological grading of CA breast on FNAC and its correlation with histological grading.

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